Diabetes and obesity are two of the most pressing issues that many are struggling with. Researchers have found a hopeful way to battle against them with a specific strain of gut bacteria. The gut bacteria seem to have improved insulin resistance and the development of Type-2 diabetes. The study also shows effectiveness against obesity. Let’s have a closer look at the findings of this incredible research.
Research Findings
RIKEN Center for Integrative Medical Sciences in Japan has conducted the study. The research was led by the scientist Hiroshi Ohno who has discovered this gut bacteria type that is effective in treating diabetes. The study was published in the Nature Journal on August 30, 2023.
The study has examined metabolites in the feces of over 300 adults at their regular health checkups. The research team compared the metabolites with insulin resistance levels of the same group of people.
“We found that higher insulin resistance was associated with excessive carbohydrates in the fecal matter,” says Ohno, the leading scientist of the study.
Next, they analyzed and characterized the gut microbiota of each participant. The findings have led them to build a relationship between gut microbiota, insulin resistance levels, and fecal carbohydrates. The gut dominated by Lachnospiraceae seems to have higher insulin resistance and excess fecal carbohydrates than others. On the other hand, insulin resistance levels and fecal carbohydrates were lower in guts that had more Bacteroidales-type bacteria than others.
“These findings need to be verified in human clinical trials before we can recommend any probiotic as a treatment for insulin resistance,” says Ohno.
Since Insulin resistance can lead to obesity, the study shows hope in battling obesity with gut bacteria as well. However, the studies regarding the issue of obesity and gut bacteria have yet to undergo human clinical trials. The experiments on obesity have so far gone through trials with mice.
Conclusion
Diabetes and obesity are two of the most pressing issues that many are struggling with. Researchers have found a hopeful way to battle against them with a specific strain of gut bacteria. RIKEN Center for Integrative Medical Sciences in Japan has conducted the study. The research was led by the scientist Hiroshi Ohno who has discovered this gut bacteria type that is effective in treating diabetes.
Journal Reference:
“Gut microbial carbohydrate metabolism contributes to insulin resistance” by Tadashi Takeuchi, Tetsuya Kubota, Yumiko Nakanishi, Hiroshi Tsugawa, Wataru Suda, Andrew Tae-Jun Kwon, Junshi Yazaki, Kazutaka Ikeda, Shino Nemoto, Yoshiki Mochizuki, Toshimori Kitami, Katsuyuki Yugi, Yoshiko Mizuno, Nobutake Yamamichi, Tsutomu Yamazaki, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki, Erik Arner, Piero Carninci, Osamu Ohara, Makoto Arita, Masahira Hattori, Shigeo Koyasu and Hiroshi Ohno, 30 August 2023, Nature.
DOI: 10.1038/s41586-023-06466-x
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